Catherine Alix-Panabières: Excited to share our new review out in Journal of Experimental and Clinical Cancer Research
Catherine Alix-Panabières, Visiting Professor at University of Hamburg, shared on LinkedIn:
“Hot off the press!
Super excited to share our latest review just published in the top-tier Journal of Experimental and Clinical Cancer Research! Springer Nature!
Dive into the world of Natural Killer Cells: the Immune Frontline against Circulating Tumor Cells.
Read it here and enjoy.
It’s open access – free to read and share!
Let’s spread the science!
Natural killer (NK) play a key role in controlling tumor dissemination by mediating cytotoxicity towards cancer cells without the need of education. These cells are pivotal in eliminating circulating tumor cells (CTCs) from the bloodstream, thus limiting cancer spread and metastasis.
However, aggressive CTCs can evade NK cell surveillance, facilitating tumor growth at distant sites. In this review, we first discuss the biology of NK cells, focusing on their functions within the tumor microenvironment (TME), the lymphatic system, and circulation. We then examine the immune evasion mechanisms employed by cancer cells to inhibit NK cell activity, including the upregulation of inhibitory receptors.
Finally, we explore the clinical implications of monitoring circulating biomarkers, such as NK cells and CTCs, for therapeutic decision-making and emphasize the need to enhance NK cell-based therapies by overcoming immune escape mechanisms.
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