Matt Sagan/X
Jun 22, 2025, 01:25
Matt Sagan: Cancer Vaccines and the future of immunotherapy
Matt Sagan, Founder, Managing Partner and CEO of MoD Partners and Executive Director of BioForum Accelerator, shared a post on X:
” ‘Cancer Vaccines and the future of immunotherapy’ super review at The Lancet is a great article (just had a chance to read it).
As its pay-per-view article I’m not allowed to make it public.
I will point out key lessons learned for everyone interested in the subject:
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More effective cancer vaccines are being developed through having a deeper understanding of crucial cellular factors in tumor immunology;
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CancerVaccines generally aim to deliver antigens to dendritic cells, which are the most potent activators of antigen-specific Tcells. Once the T cells are activated, they will expand, mobilise, and kill cancer cells systemically;
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Newer vaccines are being designed to improve the expansion of cancer-killing Tcells and overcome the tumoural resistance mechanisms;
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Cancer Vaccines are an important modality in the immunotherapy arsenal by enhancing the strength and breadth of anti-tumour T-cell responses, prolonging remissions in the adjuvant setting, and inducing systemic regressions of metastatic solid tumors and hematological cancers;
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Cancer Vaccines will undoubtedly become more effective in the coming decade as we further establish the biological understanding and technical capabilities for total programmable control of anti-tumor immune responses.”
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