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Highlights from ESMO Asia 2024 by Angela Lamarca
Dec 7, 2024, 14:41

Highlights from ESMO Asia 2024 by Angela Lamarca

The ESMO Asia Congress 2024 is currently taking place from December 6 to 8, 2024, in Singapore. This annual congress focuses on multidisciplinary oncology in the Asian region, providing a platform for participants to share and discuss the latest research findings, clinical trials, and treatment strategies in the field.

Angela Lamarca, HPB and NET Medical Oncologist at Jimenez Diaz Foundation, shared some insights from the conference as follows:

“Great session today at ESMOAsia24

A pleasure to co-chair with SuPunChoo. Thanks to the authors and discussants for a great job and fantastic discussions.”

Angela Lamarca

“Update form CHECKMATE-9DW trial in HCC – Asian population with IpiNivo

94% with lenva in control arm Similar benefit despite higher VHB (62%) – aetiology of no much relevance (again).

Less use of high dose steroids (vs general population).”

Angela Lamarca

“Update form HERIZON-BTC-01 trial in HER2 positive Biliary Cancer – Asian population with Zanidatamab

Higher rate of HER-2 2+ included (28% vs 13% in general population).

Similar ORR 42%.

Safety.”

Angela Lamarca

“Early results of TOURMALINE trial in Biliary Cancer at The European Society for Medical Oncology (ESMO) ESMOAsia24

Durvalumab being tested with nonCisGem chemotherapy, PS2 or ampullary.

Early results from first 62 pts (non-european) treated with 1hour infusion in cycle 1 and 30 min in cycle =>2. 30 min infusion is safe.”

Angela Lamarca

By the way beautiful discussion by Lorenza Rimassa. Here the behind the scenes.

Angela Lamarca

We do travel a lot on our own, but we are never really alone

Great to see you Matteo Lambertini, as usual at ESMOAsia24 ESMOLGP.”

Angela Lamarca

“Revisiting Malignant Ascitis in The European Society for Medical Oncology (ESMO) ESMOAsia24

Intraperitoneal M701 (anti-EpCAM x anti-CD3 bispecific antibody)+systemic therapy.

Puncture-free survival as end-point.”

Angela Lamarca

“So coming back to TP53 Y220C mutation Topic discussed at ESMOAsia24

Targetable alteration. Present on 8% of #PDAC (94% with KRAS co-mutated).

Please, please review carefully the NGS report. An opportunity not to be missed PYNNACLE trial.”

Angela Lamarca

“Combined Tissue and combined tissue DNA NGS in solid tumours

Combined NGS detects more targetable alterations.

Combined Tissue DNA is quick and can change practice even more than tissue.”

Angela Lamarca

MO138 in Biliary Cancer at The European Society for Medical Oncology (ESMO) ESMOAsia24 by Lorenza Rimassa

ProvIDHe: phIIIb – Ivosidenib – mIDH1 (iCCA). Awaited safety/activity – heavily pretreated (>ClarIDHy) SOC NGS for IDH  (=ClaIDHy (central)). ProvIDHE – 45 Spanish patients could access Ivosidenib.

Funding?”

Angela Lamarca

“MO132 in PDAC at The European Society for Medical Oncology (ESMO) ESMOAsia24

IBI343 – Claudine 18.2 ADC (exatecan). ORR 23.3%, mPFS 5.3m (46.5% prior irinotecan).
Good safety – could it be combined? Expresion of Claudine 18.2 in PDAC – 20-40% of pts approximately.
Promising target – lets find these patients.”
Angela Lamarca

Angela Lamarca, MD, PhD, MSc, is a Consultant in Medical Oncology at Jiménez Díaz Foundation University Hospital and The Christie NHS Foundation Trust. She also serves as an Honorary Consultant in Medical Oncology and Honorary Senior Lecturer at The University of Manchester. Dr. Lamarca specializes in gastrointestinal malignancies, particularly hepato-pancreato-biliary (HPB) cancers and neuroendocrine tumors (NETs).

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