Amol Akhade/hiranandanihospital.org
May 29, 2025, 17:41
Amol Akhade: Can Perioperative Immunotherapy Change Outcomes in Resectable Gastric/GEJ Cancer?
Amol Akhade, Consultant Medical Oncologist at the Suyog Cancer Clinics, shared a post on LinkedIn:
“MATTERHORN Trial – ASCO 2025 Spotlight
Can perioperative immunotherapy change outcomes in resectable gastric/GEJ cancer?
At GI25, MATTERHORN (Durvalumab + FLOT) showed:
- pCR: 19% vs 7%
- T0: 23% vs 11%
- N0: 52% vs 36%
As Per press release: EFS is statistically significant and clinically meaningful.
But KN585 – PCR BENIFIT but no EFS gain
Why MATTERHORN may succeed where KEYNOTE-585 fell short:
- 100% got triplet chemo (vs 20% in KN585)
- 60% completed peri-op FLOT (vs 48 % )
Now your turn- put your brain and give me your best guess for the EFS outcome?
HR and Gain in median EFS.
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Challenging the Status Quo in Colorectal Cancer 2024
December 6-8, 2024
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ESMO 2024 Congress
September 13-17, 2024
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ASCO Annual Meeting
May 30 - June 4, 2024
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Yvonne Award 2024
May 31, 2024
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OncoThon 2024, Online
Feb. 15, 2024
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Global Summit on War & Cancer 2023, Online
Dec. 14-16, 2023
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