Yüksel Ürün: Our comment about ‘Cardiovascular Events and Androgen Receptor Signaling Inhibitors in Advanced Prostate Cancer’

Yüksel Ürün shared on X:

“Our comment about ‘Cardiovascular Events and Androgen Receptor Signaling Inhibitors in Advanced Prostate Cancer’.

Congrats Omar El-Taji et al. for this comprehensive M-A.

Novel androgen receptor signaling inhibitors (ARSI) have revolutionized prostate cancer treatment but pose cardiovascular (CV) risks.

Key Findings:

ARSI increases the risk of all-grade CV events and severe CV events.
Notable risks include hypertension, ACS, cardiac dysrhythmia, cerebrovascular events, and CV-related death.

Mechanism and Side Effects:

Abiraterone Acetate: Different action mechanism compared to AR antagonists, affecting cardiovascular system due to mineralocorticoid precursor production.
AR Antagonists: Distinct drug-drug interaction profiles and cardiovascular impact.

Study Suggestion:
Evaluation of Abiraterone and AR antagonists as separate subgroups for a clearer understanding of their distinct side effect profiles.”

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Source: Yüksel Ürün/X

Yüksel Ürün is a Medical Oncology professor at Ankara University School of Medicine in Turkey. His research focuses on genitourinary cancers, covering epidemiology, diagnosis, biomarkers, meta-analysis, and treatment outcomes. His dedication to patient care and research inspires positive change in the medical field.