Krishna Komanduri: Nice CIBMTR study of CAR-T outcomes for DLBCL in CR

Krishna Komanduri, Physician in Chief at UCSF Helen Diller Family Comprehensive Cancer Center, shared a post by Ajay Major, Assistant Professor at the University of Colorado School of Medicine and Founder and President at Pager Publications, posted on X:

“Nice CIBMTR study of CAR-T outcomes for DLBCL in CR led by my former Sylvester Comprehensive Cancer Center colleagues Trent Wang and Antonio Jimenez Jimenez. I’m a little disappointed that outcomes are not better in this group with 2 yr PFS 44%.”

Quoting Ajay Major‘s post:

“Outcomes for DLBCL in CR at time of CAR-T infusion from CIBMTR:
– 134 patients, median 3 LOT
– 2-yr PFS 44%, OS 64%
– no diff in outcomes if PET done <1 vs >1 month before CAR

Outcomes same as active disease. Would be great to study RT v chemo bridging. ”

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Source: Krishna Komanduri/X and Ajay Major/X