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Deniz Can Guven: The 1st-in-human phase 1 study on arginase inhibitor INCB001158
May 18, 2024, 06:04

Deniz Can Guven: The 1st-in-human phase 1 study on arginase inhibitor INCB001158

Deniz Can Guven, Medical Oncologist at , shared on X/Twitter:

The 1st-in-human phase 1 study on arginase inhibitor INCB001158 is out on BMJ Oncology.

Led by my great mentor Aung Naing.

Tested a strong preclinical hypothesis:

  • A total of 107 patients.
  • Monotherapy or with pembrolizumab.
  • + Tolerable with fatigue and GI adverse events.
  • – Very limited efficacy.

Need more data on the role of arginine metabolism in TME immunosuppression. Kudos to all authors.”

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Source: Deniz Can Guven/X