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Gaurav Prakash: How to read an HLA report
May 18, 2024, 09:44

Gaurav Prakash: How to read an HLA report

Gaurav Prakash, Medical Oncologist at Postgraduate Institute of Medical Education and Research, Chandigarh, shared on their X/Twitter:

How to read an HLA report? A thread on understating HLA typing for BMT.

Key slides from my talk at ISBMT Annual Meeting.

Gaurav Prakash

  • Usually, a high resolution HLA typing is done for finding a donor for BMT.
  • It employs Next generation sequencing.

As a result the report comes in form of a combination of many letters and numbers. This slides explains 4 major fields of HLA report.

Gaurav Prakash

The last two suffixes in HLA nomenclature, in this case 02: 14, are not used for HLA matching in routine clinical practice.

Their interpretation is as follows.

Gaurav Prakash

What do we understand by ‘low resolution typing’?

Gaurav Prakash

And what is a ‘high resolution typing’?

Gaurav Prakash

The last point is a bit complex it is direction of HLA mismatch.

  • A mismatch in graft vs host direction increases risk of GVHD.
  • A mismatch in host vs graft direction increases risk of graft loss.

Gaurav Prakash

Ending this thread¬†with tributes to these 3 eminent scientists who discovered HLA and revolutionized the field of immunology and BMT. They were awarded Nobel prize for medicine in 1980.”

Gaurav Prakash

Source: Gaurav Prakash/X