Gaurav Prakash: How to read an HLA report
Gaurav Prakash, Medical Oncologist at Postgraduate Institute of Medical Education and Research, Chandigarh, shared on their X/Twitter:
”How to read an HLA report? A thread on understating HLA typing for BMT.
Key slides from my talk at ISBMT Annual Meeting.
- Usually, a high resolution HLA typing is done for finding a donor for BMT.
- It employs Next generation sequencing.
As a result the report comes in form of a combination of many letters and numbers. This slides explains 4 major fields of HLA report.
The last two suffixes in HLA nomenclature, in this case 02: 14, are not used for HLA matching in routine clinical practice.
Their interpretation is as follows.
What do we understand by ‘low resolution typing’?
And what is a ‘high resolution typing’?
The last point is a bit complex it is direction of HLA mismatch.
- A mismatch in graft vs host direction increases risk of GVHD.
- A mismatch in host vs graft direction increases risk of graft loss.
Ending this thread with tributes to these 3 eminent scientists who discovered HLA and revolutionized the field of immunology and BMT. They were awarded Nobel prize for medicine in 1980.”
Source: Gaurav Prakash/X