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Breakdown of T cell therapies deployed to treat autoimmune diseases by Jeffrey C. Martin
Apr 24, 2024, 22:41

Breakdown of T cell therapies deployed to treat autoimmune diseases by Jeffrey C. Martin

Jeffrey C. Martin, Founder of Oncoleader, shared a post on LinkedIn:

“T cell therapies are now being deployed to treat autoimmune diseases. Here’s a quick breakdown.

T cell therapies, particularly CAR-T cells, have displayed potent anti-cancer activity against blood-based cancers, especially CD19+ B cell malignancies.

CAR T cells are basically highly cytotoxic T cells, designed to seek out and destroy any cell that expresses a particular protein on its surface – in the case of CD19+ malignancies, the target is CD19.

Once they’re inject into a cancer patient, they destroy all the CD19+ B cells. Easy-peasy… (it’s not really all that easy, but you get the point).

But hang on…hyperactive B cells (and T cells) are also the cause of several autoimmune diseases…

So, wouldn’t a patient suffering from an autoimmune disease also benefit from the directed killing of B cells? Couldn’t scientists design CAR T cells to seek out and kill the B cells that are responsible for the autoimmune disease?

YEP!

Several CAR T biotech companies have taken aim at autoimmune diseases and are now deploying these therapies to treat autoimmune diseases.

There seems to be three main approaches:

1. CAR T cells directed towards an entire immune cell population such as CD19+ B cells.

2. Chimeric auto-antigen receptor (CAAR) T cells – these cells will find and kill the immune cells that are ‘personally’ responsible for causing the autoimmunity.

3. CAR/TCR Treg cells – these cells use their CAR (or synthetic T cell) receptor to traffic to the site of the autoimmune reaction, and suppress the local immune activity.

I’ve compiled a list of the companies, their products, and the diseases they target below!

—–

  • Cabaletta Bio is developing a CD19-specific CAR T called CABA-201 that is being used to treat Systemic Lupus erythematosus the most common type of Lupus.
  • Kynerna Therapeutics has also developed a CD19 CAR that they are deploying against several autoimmune diseases including myasthenia gravis and lupus nephritis.
  • Sonoma Biotherapeutics and their CAR Treg platform SBT-77-7101 are fighting rheumatoid arthritis and hidradenitis suppurativa.
  • Sonoma also just announced a $120 million partnership with Renergon to develop CAR Treg cells for the treatment of IBD and Crohn’s disease.
  • Abata Therapeutics is generating two CAR Treg platforms: i) ABA-101 for the treatment of progressive Multiple Sclerosis, and ii) ABA-201 for Type I Diabetes.
  • GentiBio’s GNTI-122 is a CAR Treg platform for the treatment of new onset Type I Diabetes.
  • Deeks and Abedi are collaborating to develop a CAR T cell therapy for the treatment of HIV Source
  • for most of the information on the various therapies being developed is linked in the comments.”

Jeffrey C. Martin

Source: Jeffrey C. Martin/LinkedIn


About OncoDaily

OncoDaily was founded in 2023. It is a US-based oncology media platform, which features the latest news, insights, and patient stories from the world of oncology. Within short period of time it became one of the leading oncology media platforms globally.

OncoDaily gathers content from various sources, including social media posts from renowned oncologists from all over the world, news from oncology societies and cancer centers, patient and survivor stories, and career-related information for professionals.

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