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Feb 13, 2024, 07:21

Vincent Rajkumar: Updated mSMART recommendations for treatment of newly diagnosed myeloma

Vincent Rajkumar, Professor of Medicine at the Mayo Clinic in Rochester, Minnesota, shared a post on X/Twitter:

“Just out: Updated mSMART recommendations for treatment of newly diagnosed myeloma.

Dara VRd is now a recommended frontline regimen for all transplant eligible patients. VRd is still included as a reasonable alternative for standard risk patients since we do not have data that OS is improved with Dara VRd compared to VRd induction; there are also significant problems of cost and access around the world.

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No change to algorithm for transplant ineligible. DRd is preferred. VRd is a reasonable alternative.

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Tandem transplant is removed from the algorithm for high risk patients. We rarely recommend or do this in practice. Del 1p added to risk stratification.

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All mSMART guidelines are downloadable in both PDF and PowerPoint formats on mSMART.org

Source: Vincent Rajkumar/X