
Shankar Siva/iconcancercentre.com.au
Mar 28, 2025, 14:03
Shankar Siva: OMET trial in oligometastatic HNSCC
Shankar Siva, Radiation Oncologist at Peter MacCallum Cancer Centre, shared a post on X:
“OMET trial (GORTEC 2014-04) in oligometastatic HNSCC.
N=69, SABR alone vs SABR + chemo + cetuximab.
Key finding:
- Similar 1-year OS without QoL (SABR 55.2% vs chemo-SABR 53.3%).
- SABR alone had toxicity and QoL impact.
- Gr 3–4 tox: 8.8% (SABR alone) vs 60%.
Survival Without Quality of Life Deterioration in the GORTEC 2014-04 “OMET” Randomized Phase 2 Trial in Patients with Head and Neck Cancer with Oligometastases using Stereotactic Ablative Radiation Therapy (SABR) alone or Chemotherapy and SABR.
Authors: Juliette Thariat, et al.
Phase II randomized design:
- 1–3 oligometastases, mostly lung.
- Median OS ~42 mo both arms.
- QoL deterioration (median drop):
– SABR: 16.7 patients.
– Chemo-SABR: 50 patients.
QoL assessed with EORTC QLQ-C30.”
Toxicity snapshot:
Grade ≥3 toxicity:
- 60% with chemo vs 8.8% with SABR-only.
- No grade 5 events.
- Chemo toxicities: anemia, nausea, mucositis, hypomagnesemia, etc.
QoL declines closely linked to non-haem grade ≥3 toxicities.”
Bottom line for clinicians:
In select patients with oligometastatic HNSCC, SABR alone offers comparable survival with toxicity and better QoL.
Repeated SABR feasible at relapse SABR-only arm also shown to be cost-efficient.
Full paper.
Sue Yom–ASTRO upcoming podcast for APRIL 2025.”
anemia
ASTRO
cancer
cetuximab
chemotherapy
EORTC
fight against cancer
Global fight against cancer
GORTEC
Head and Neck Cancer
HNSCC
hypomagnesemia
Juliette Thariat
mucositis
nausea
Oligometastases
OMET
OncoDaily
Oncology
Peter MacCallum Cancer Centre
quality of life
RadOnc
SABR
Shankar Siva
Stereotactic Ablative Radiation Therapy
Sue Yom
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