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Yan Leyfman: Off-the-shelf CAR T cells could be a viable option for R/R T-cell Lymphoma - OncoDaily
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Yan Leyfman: Off-the-shelf CAR T cells could be a viable option for R/R T-cell Lymphoma
Yan Leyfman
Feb 20, 2025, 08:27

Yan Leyfman: Off-the-shelf CAR T cells could be a viable option for R/R T-cell Lymphoma

Yan Leyfman, Co-founder and executive director of MedNews Week, shared an article Swaminathan P. Iyer and colleagues authored on LinkedIn:

“New study spearheaded by researchers from MD Anderson Cancer Center and Memorial Sloan Kettering Cancer Center on CTX130, a CAR T-cell therapy for relapsed/refractory T-cell lymphoma, has been completed across the USA, Australia, and Canada. The phase 1 trial included 39 heavily pre-treated patients.

Key Findings:

Safety: Manageable, with cytokine release syndrome being the most common side effect (67% of patients).
Efficacy: 46.2% of patients showed an objective response, with improved results at higher doses (51.6%).

This study indicates that off-the-shelf CAR T cells could be a viable option. Next, CTX131, an enhanced version, is in development.”

Safety and activity of CTX130, a CD70-targeted allogeneic CRISPR-Cas9-engineered CAR T-cell therapy, in patients with relapsed or refractory T-cell malignancies (COBALT-LYM): a single-arm, open-label, phase 1, dose-escalation study

Authors: Swaminathan P. Iyer et al.

Yan Leyfman

Alissa Keegan Amer Beitinjaneh Anca Prica Anna Ma Auris O. Huen Avanti Ganpule Boyu Hu cancer Elaine Huang Erika L. Cullingford Francine M. Foss Janki N. Patel Jasmine Zain Joy H. Mendonez Leah M. Williams Mary-Lee Dequeant MD Anderson Cancer Center Memorial Sloan Kettering Cancer Center Michael S. Khodadoust OncoDaily Oncology P. Joy Ho Parin Sripakdeevong Qiuling Ally He R. Alejandro Sica Shashwat Deepali Nagar Steven M Horwitz. Sushant Karnik Swaminathan P iyer Wen-Kai Weng Xinyi Shirley He Yan Leyfman Youn H. Kim Ziliang Li
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