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Vincenzo Corbo: MAPKhigh myCAF phenotype linked to immunotherapy resistance
Vincenzo Corbo/X
Dec 7, 2024, 10:51

Vincenzo Corbo: MAPKhigh myCAF phenotype linked to immunotherapy resistance

Vincenzo Corbo, Associate Professor at University of Verona, posted the following on X:

“Thrilled to share our Nature Communications paper! We uncover a MAPKhigh myCAF (mapCAF) phenotype enriched in basal-like/squamous PDAC regions and extend evidence of this stromal signature to other tumors, linking it to immunotherapy resistance.”

Differential activity of MAPK signalling defines fibroblast subtypes in pancreatic cancer

Authors: Lisa Veghini, Davide Pasini, Rui Fang, Pietro Delfino, Dea Filippini, Christian Neander, Caterina Vicentini, Elena Fiorini, Francesca Lupo, Sabrina L. D’Agosto, Carmine Carbone, Antonio Agostini, Geny Piro, Diego Rosa, Michele Bevere, Peter Markus, Diana Behrens, Claudio Luchini, Rita T. Lawlor, Aldo Scarpa, Giulia Biffi, Phyllis F. Cheung, Jens T. Siveke & Vincenzo Corbo

Vincenzo Corbo: MAPKhigh myCAF phenotype linked to immunotherapy resistance

cancer Cancer research cancer therapies immunotherapy resistance MAPKhigh myCAF Nature Communications OncoDaily Oncology PDAC squamous tumors stromal signature targeted therapies tumor microenvironments Vincenzo Corbo
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