Concurrent thoracic radiotherapy improves the PFS and OS with acceptable toxicity in EGFR-mutated NSCLC
Gustavo Viani shared a post on Linkedin:
”Concurrent thoracic radiotherapy improves the PFS and OS with acceptable and tolerable toxicity in patients with EGFR-mutated oligo-organ metastatic NSCLC.
Target OBJECTIVE
• Investigate whether combining first-line lung cancer (TRT) with EGFR-TKIs high survival compared to EGFR-TKIs alone in patients with EGFR-mutated oligo-organ metastatic non-small cell lung cancer (NSCLC)
Laboratory METHODS :
• Multicenter, randomized, phase III trial (Northern Radiation Oncology Group of China-002)
• 118 patients enrolled between April 2016 and February 2022
• patients in the TKI + lung cancer group received 60 Gy cancer to primary tumors and positive regional lymph nodes
• PFS was the first endpoint, with OS and treatment-related adverse events (TRAEs) as second endpoints
RESULTS:
• High The TKI + lung cancer group had significantly better outcomes:
• High PFS: 17.1 months vs 10.6 months (TKI alone); HR 0.57, P = .004
• High OS: 34.4 months vs 26.2 months (TKI alone); HR 0.62, P = .029.
• local control but high incidence of severe TRAEs (11.9% vs 5.1%).”
Authors: Hongfu Sun, Minghao Li, Wei Huang, Jian Zhang, Shihong Wei, Yongjing Yang, ZhongtangWang, Shucheng Ye, Heyi Gong, Yaowen Zhang, Jie Li, Haixia Song, Lifang Wang, XiangmingChen, Haiqun Lin, Gaofeng Ding, Hongwei Li, Anping Zheng, Xuezhen Ma, ShaoShui Chen, Liping Liu, Kaixian Zhang, Chengrui Fu, Wenzhi Liu, Jing Wang, Xiaqin Zhang, Tingting Liu, Dan Han, QianZhao, Peipei Wu, Qianqian Yuan, LiJun Tian, Ping Zhang, Xueqin Wu, Fei Chen, Zicheng Zhang and Baosheng Li.
Gustavo Viani, MD is an Associate Professor in the Department of Medical Imaging, Hematology, and Oncology at Hospital das Clínicas, Faculty of Medicine of Ribeirão Preto, University of São Paulo (FMRP-USP). Dr. Viani’s research focuses on radiation oncology, with expertise in brachytherapy, stereotactic radiosurgery, dose fractionation, radiation tolerance, and overall oncology practices.
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