Triparna Sen: DDR protein ATR activation enhances immunotherapy in SCLC

Triparna Sen posted the following on X:

“Thank you Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute for the press release of our work now published in Science Advances demonstrating that targeting DDR protein ATR activates the cGAS-STING pathway, induces immune cell infiltration, and enhances response to immunotherapy in SCLC. a very aggressive form of lung cancer.

Link to the paper.
Press release.
See thread for further details.”

ATR inhibition activates cancer cell cGAS/STING-interferon signaling and promotes antitumor immunity in small-cell lung cancer

Authors: Hirokazu Taniguchi, Subhamoy Chakraborty, Nobuyuki Takahashi, Avisek Banerjee, Rebecca Caeser, Yingqian A Zhan, Sam E Tischfield, Andrew Chow, Evelyn M Nguyen, Álvaro Quintanal Villalonga, Parvathy Manoj, Nisargbhai S Shah, Samantha Rosario, Omar Hayatt, Rui Qu, Elisa de Stanchina, Joseph Chan, Hiroshi Mukae, Anish Thomas, Charles M Rudin, Triparna Sen.

Source: Triparna Sen/X

Triparna Sen is an Associate Professor at the Icahn School of Medicine at Mount Sinai. She was previously an assistant attending at the Memorial Sloan Kettering Cancer Center. She also served as a research associate at Indian Institute of Chemical Biology.