Sendurai Mani: Amazing meeting and great presentation by Dr. Senthil Muthuswamy from NCI

Sendurai Mani posted the following on LinkedIn:

“It was an amazing meeting, and great presentation by Dr. Senthil Muthuswamy from the National Cancer Institute (NCI). Special thanks to Dr. Wafik S. El-Deiry, MD, PhD, FACP, Shiyoko Cothren, MHA, FACHE, Henri Blouin, and all others at Brown University Legorreta Cancer Center for their support and active participation.”

Quoting Wafik S. El-Deiry’s post:

“Dr. Senthil Muthuswamy at the National Cancer Institute (NCI) speaks at the 2nd annual translational oncology symposium organized by Sendurai Mani at the Legorreta Cancer Center @BrownUCancer The Warren Alpert Medical School of Brown University.

Dr. Muthuswamy spoke about the dual roles of cell polarity, interactions with oncogenes, LGL1/2 in ER/PR+ breast cancer, nutrient stress, leucine, the leucine transporter SLC7A5 interaction with LgL2, regulation of LGL2 by ER, links with mTOR and glycolytic metabolism. He also spoke organoids for personalized cancer treatment at NCI, organoids to identify tumor-targeting T-cells, and cytotoxic organoid primed T-cells. Lots of work to identify TCR-binding antigens including anti-sense Mcl1.”

Source: Sendurai Mani/LinkedIn and Wafik S. El-Deiry/LinkedIn

Sendurai A. Mani is a distinguished Indian-American oncologist and molecular biologist. Currently holding the Dean’s Chair for Translational Oncology at Brown University Warren Alpert Medical School, Dr. Mani also serves as the Associate Director for Translational Oncology at the Legorreta Cancer Center at Alpert Medical School.

Prior to his current roles, he held positions as Co-Director of the Metastasis Research Center and the Center for Stem Cell and Developmental Biology, as well as Professor of Translational Molecular Pathology at UT MD Anderson Cancer Center.

Wafik S. El-Deiry, MD, PhD, FACP, FRSM, is the Associate Dean for Oncologic Sciences at the Warren Alpert Medical School and Director of the Legorreta Cancer Center at Brown University and Director of the Joint Program in Cancer Biology at Brown University and affiliated hospitals.

He is the Editor in Chief at Oncotarget. Dr. El-Deiry discovered p21(WAF1) as a p53 target gene, cell cycle inhibitor, and tumor suppressor that explained the mammalian cell stress response. Dr. El-Deiry’s research is focused on mechanisms of therapy resistance with major efforts in drug discovery and development.