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Michael Rothenberg: A next generation BRAF Inhibitor shows promise in treatment refractory cancer patients
Photo taken from S. Michael Rothenberg/LinkedIn
Sep 9, 2024, 17:52

Michael Rothenberg: A next generation BRAF Inhibitor shows promise in treatment refractory cancer patients

Michael Rothenberg, Chief Medical Officer at I

“The Pfizer, Pfizer Boulder Research Unit, and academic collaborators’ clinical and translational work on PF-07799933 (ARRY-440) is out in the September issue of Cancer Discovery. A next-generation, brain-penetrant, pan-mutant BRAF-selective inhibitor, together with innovative and accelerated phase 1 clinical development with demonstrated efficacy in treatment-refractory cancer patients.”

A Next-Generation BRAF Inhibitor Overcomes Resistance to BRAF Inhibition in Patients with BRAF-Mutant Cancers Using Pharmacokinetics-Informed Dose Escalation 

Authors: Rona Yaeger, Meredith A. McKean, Rizwan Haq, J. Thaddeus Beck, Matthew H. Taylor, Jonathan E. Cohen, Daniel W. Bowles, Shirish M. Gadgeel, Catalin Mihalcioiu, Kyriakos P. Papadopoulos, Eli L. Diamond, Keren B. Sturtz, Gang Feng, Stefanie K. Drescher, Micaela B. Reddy, Bhaswati Sengupta, Arnab K. Maity, Suzy A. Brown, Anurag Singh, Eric N. Brown, Brian R. Baer, Jim Wong, Tung-Chung Mou, Wen-I Wu, Dean R. Kahn, Sunyana Gadal, Neal Rosen, John J. Gaudino, Patrice A. Lee, Dylan P. Hartley, S. Michael Rothenberg

Michael Rothenberg: A next generation BRAF Inhibitor shows promise in treatment refractory cancer patients

Source: Michael Rothenberg/LinkedIn

Anurag Singh Arnab K. Maity Bhaswati Sengupta BRAF-selective inhibitor Brian R. Baer cancer Cancer Discovery Catalin Mihalcioiu Daniel W. Bowles Dean R. Kahn Dylan P. Hartley Eli L. Diamond Eric N. Brown Gang Feng J. Thaddeus Beck Jim Wong John J. Gaudino Jonathan E. Cohen Keren B. Sturtz Kyriakos P Papadopoulos Matthew H. Taylor Meredith A. McKean Micaela B. Reddy Michael Rothenberg Neal Rosen OncoDaily Oncology Patrice A. Lee Rizwan Haq Rona Yaeger S. Michael Rothenberg Shirish M. Gadgeel Stefanie K. Drescher Sunyana Gadal Suzy A. Brown Tung-Chung Mou Wen-I Wu
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