Toni Choueiri: An elegant paper about renal cell cancer tumor metabolism by DeBerardinis Lab

Toni Choueiri shared a post by Divya Bezwada, Postdoctoral Fellow at Scripps Research, on X, adding:

“This is such an elegant paper about renal cell cancer tumor metabolism in Nature : Tricarboxylic Acid (TCA) cycle is suppressed in primary Clear cell renal cell carcinoma (ccRCC) but enhanced in metastatic ccRCC, work in humans and mice! Much respect DeBerardinis Lab and Team UT Southwestern Medical Center.”

Quoting Divya Bezwada’s post about her recent paper, commenting:

“Glad to finally see this paper online. Using observations in humans and functional data in mice, we demonstrate that mitochondrial complex I is both necessary and sufficient for efficient kidney cancer metastasis.”

Mitochondrial complex I promotes kidney cancer metastasis published in Nature.

Authors: Divya Bezwada, Luigi Perelli, Nicholas P. Lesner, Ling Cai, Bailey Brooks, Zheng Wu, Hieu S. Vu, Varun Sondhi, Daniel L. Cassidy, Stacy Kasitinon, Sherwin Kelekar, Feng Cai, Arin B. Aurora, McKenzie Patrick, Ashley Leach, Rashed Ghandour, Yuanyuan Zhang, Duyen Do, Phyllis McDaniel, Jessica Sudderth, Dennis Dumesnil, Sara House, Tracy Rosales, Alan M. Poole, Yair Lotan, Solomon Woldu, Aditya Bagrodia, Xiaosong Meng, Jeffrey A. Cadeddu, Prashant Mishra, Javier Garcia-Bermudez, Ivan Pedrosa, Payal Kapur, Kevin D. Courtney, Craig R. Malloy, Giannicola Genovese, Vitaly Margulis and Ralph J. DeBerardinis.

Additional information Source: Toni Choueiri/X and Divya Bezwada/X

Toni Choueiri is the Director of the Lank Center for Genitourinary (GU) Oncology at Dana-Farber Cancer Institute (DFCI), co-leader of the Kidney Cancer Program at Dana-Farber/Harvard Cancer Center, and the Jerome and Nancy Kohlberg Chair and Professor of Medicine at Harvard Medical School. He is the Medical Director of International Strategic Initiatives at Dana-Farber and past President of the Medical Staff at DFCI (2016-2018).