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Joshua Zeidner: Highly impactful data for R/R AML and menin inhibitors
Aug 12, 2024, 01:35

Joshua Zeidner: Highly impactful data for R/R AML and menin inhibitors

Joshua Zeidner, Associate Professor at UNC Lineberger, shared a post by Ghayas Issa, Leukemia Physician at MD Anderson Cancer Center, on X:

Glad to see this data finally in print! Congratulations- this is really fantastic. Highly impactful data for a subset of R/R AML with otherwise dismal outcomes. Hoping menin inhibitors may represent a new standard of care.

Quoting Ghayas Issa‘s post:

“Revumenib phase 2 for R/R KMT2Ar finally out! ORR 63%, CR/CRh 23%, MRD neg 70%. Result filed for FDA approval.

Menin Inhibition With Revumenib for KMT2A-Rearranged Relapsed or Refractory Acute Leukemia (AUGMENT-101)

Authors:  Ghayas C. IssaIbrahim AldossMichael J. Thirman, John DiPersioMartha Arellano, James S. Blachly, Gabriel N. Mannis, Alexander PerlDavid S. DickensChristine M. McMahon, Elie TraerC. Michel Zwaan, Carolyn S. Grove, Richard Stone, Paul J. Shami, Ioannis Mantzaris, Matthew Greenwood, Neerav Shukla, Branko Cuglievan,Tibor Kovacsovics, Yu Gu, Rebecca G. BagleyKate Madigan, Yakov Chudnovsky,Huy Van Nguyen, Nicole McNeer, and Eytan M. Stein.

Joshua Zeidner: Highly impactful data for R/R AML and menin inhibitors

Source: Joshua Zeidner/X and Ghayas Issa/X