Vedang Murthy: Late urinary toxicity after hypofractionated prostate radiation in patients with prior TURP
Vedang Murthy, Professor GU-Radiation Oncology at Tata Memorial Centre Mumbai, shared a post on X, about recent paper published in International Journal of Radiation Oncology – Biology – Physics (IJROBP):
Authors: Maneesh Singh, Priyamvada Maitre, Anuradha Krishnan, Ketaki Adsul, Sarath Mini Sreekumar, Harshdeep Chauhan, Pranav Narayan Bishnu, Reena Phurailatpam, Pallavi Singh, Divya Kamble, Ganesh Bakshi, Mahendra Pal, Amandeep Arora, Ankit Misra, Gagan Prakash, Vedang Murthy.
”New study alert!
About 25% of patients undergoing curative radiotherapy (RT) in India have a prior history of Channel Transurethral Resection of the Prostate (TURP), mostly for disease-related obstruction.
Purpose: Investigate late urinary toxicity in prostate cancer patients post-TURP treated with moderate or extreme hypo radiotherapy (RT).
Methods: n=203 patients from Tata Memorial Hospital, ACTREC (Advanced Centre for Treatment, Research and Education in Cancer). Severity and duration of genitourinary (GU) symptoms post-RT were graded according to the Common Terminology Criteria for Adverse Events (CTCAE).
Results: At a median follow-up of 37 months, the cumulative grade 3 and grade 2 late urinary toxicity were 8.4% and 23.2%, respectively. The chief grade 3 symptoms were hematuria (6.4%) and urinary obstruction (3.4%). These were mostly temporary, but still scored as grade 3!
Time Factors:
- The median time from TURP to radiotherapy (RT) was 10 months.
- Grade 3 symptoms appeared at a median of 29 months post-RT and lasted a median of 8 months.
Source: Vedang Murthy/X