Jessie Guo: G6PD is essential for KL but not KP lung tumorigenesis

Jessie Guo, Associate Professor at Rutgers Cancer Institute of New Jersey, shared on X:

“Check out our new publication in Nature Communications. Our studies found that G6PD is essential for KL but not KP lung tumorigenesis. Thus, targeting G6PD could be a potential therapeutic strategy for tumors with KRAS and LKB1 co-mutations.

‘Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer’

Authors: Taijin Lan, Sara Arastu, Jarrick Lam, Hyungsin Kim, Wenping Wang, Samuel Wang, Vrushank Bhatt, Eduardo Cararo Lopes, Zhixian Hu, Michael Sun, Xuefei Luo, Jonathan M. Ghergurovich, Xiaoyang Su, Joshua D. Rabinowitz, Eileen White, Jessie Yanxiang Guo.”

Source: Jessie Guo/X