Yago Garitaonaindía, Translational Research Fellow at CCIT-DK – National Center for Cancer Immune Therapy of Denmark, shared on X:
“Just published in Science Magazine: germline EGFR T790M and lung cancer risk.
3.3M people (23andMe).
- Carrier frequency 1:15,850 (up to 1:2,000 in parts of Appalachia)
- OR 25 overall | ~62× in never-smokers
- No signal across 17 other cancers, no PRS interaction
- British/Irish founder effect ~200 years ago
Strongest single germline risk factor in lung cancer so far. But rare, not the never-smoker gene.”