Tuomas Tammela, Associate Member at Memorial Sloan Kettering Cancer Center, shared on LinkedIn:
“Paper out! In this study we show a malignant cell state with features of an epithelial injury-associated regenerative state drives conversion of premalignant lesions to malignancy and progression and drug resistance in advanced cancers. We are very excited about translating our findings to patients together with collaborators at Memorial Sloan Kettering Cancer Center and around the world. Congrats to lead authors Jason Chan and Chun-Hao Pan and the team and special thanks to our collaborators Zeda Zhang, Scott Lowe, and Doron Betel!”
Title: Critical role for a high-plasticity cell state in lung cancer
Authors: Jason E. Chan, Chun-Hao Pan, Jonathan Rub, Gary Guzman, Klavdija Krause, Emma Brown, Zeda Zhang, Hannah Styers, Griffin Hartmann, Zhuxuan Li, Xueqian Zhuang, Scott W. Lowe, Doron Betel, Yan Yan, Tuomas Tammela
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