Trudy Oliver, Professor at Duke University, shared a post on LinkedIn:
“Our work suggests basal cells of origin more accurately explain the phenotypes of human SCLC and probably many other human cancers with neuroendocrine and tuft-like subsets. Lineage tracing is identifying new pathways driving plasticity to these states and these new basal-derived models are being used to test new therapies.”
Title: Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer
Authors: Abbie Ireland, Daniel Xie, Sarah Hawgood, Margaret Barbier, Lisa Zuo, Benjamin Hanna, Scarlett Lucas-Randolph, Darren Tyson, Benjamin Witt, Ramaswamy Govindan, Afshin Dowlati, Justin Moser, Anish Thomas, Sonam Puri, Charles Rudin, Joseph Chan, Andrew Elliott, Trudy Oliver
Read the full article on nature.
More posts from Trudy Oliver on OncoDaily.