Foxpaws Fauxpas, Clinical Oncologist, shared a post on X about a paper
“Have the gates been finally breached? PYNNACLE thinks so!
- Rezatapopt/TP53 Y220C
- ORR 34% pantumor; 46% in ovarian ; rapid responses in ~1.3 months
All responders ctDNA VAF ↓↓
DoR ~7–8m
GI AEs ↓↓ with food.”

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