Pashtoon Kasi, Medical Director of GI Medical Oncology at City of Hope Orange County, shared on LinkedIn:
“Nest Trial
Lesson 6: The immune-suppressive milieu – mechanistic insights
Tregs crowd the ‘cold’ MSS colorectal tumor.
With BOT/BAL we are seeing Treg depletion + multi-arm immune activation within weeks – ongoing in NEST3 (Orion panel).”
Title: Neoadjuvant Botensilimab/Balstilimab for localized mismatch repair proficient and deficient colon cancer: Results of the NEST phase 2 clinical trial
Authors: Manish A. Shah, Erika Hissong, Mehraneh D. Jafari, Pashtoon Murtaza. Kasi, Maider Astorkia, Sahrish Khan, Casey Owens, Zhengming Chen, Heather Yeo, Fabio Socciarelli, Sandipto Sarkar, Alana Nguyen, Despina Siolas, Allyson Ocean, Kelly Garrett, Lea Lowenfeld, Alessio Pigazzi, Preethi Guniganti, Sanjay Patel, Doron Betel, Manuel Hidalgo.
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