Olivier Elemento, Director of Englander Institute for Precision Medicine at Weill Cornell Medicine, shared a post on LinkedIn:
“Our new paper in Science Advances characterizes 220 patient-derived tumor organoids (PDTOs) from 191 patients across 15 cancer types.
These 220 PDTOs are part of a larger pan-cancer collection at the Englander Institute at Weill Cornell Medicine, now over 400 PDTOs built up over the past decade.
The PDTOs are very faithful to the parent tumor. We see 93% histopathology match, 0.85 gene expression correlation, and 85% of dominant clones preserved. Expression also stays stable through ten passages.
The most interesting functional finding is around PARP inhibitors. Half the patients (58%) who would not qualify for FDA-approved PARP inhibitors had organoids that responded to talazoparib. Most carried DNA damage repair defects outside BRCA1/2. We saw strong synergy when combining talazoparib with temozolomide, especially in TP53-mutant tumors.
This has been a massive team effort. I want to thank M. Laura Martin, Hui-Hsuan (Helen) Kuo, Bhavneet Bhinder, Andrea Sboner, and Juan Miguel Mosquera for leading this paper, the Englander Institute team members who processed and assessed tissue, collected clinical data, performed profiling, analyzed data as well as our many clinical collaborators (all of them co-authors on paper).
And of course this could not be done without the participation of patients who agreed to donate tumor tissue.”
Title: Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities
Authors: Hui-Hsuan Kuo, Bhavneet Bhinder, Hamza N. Gokozan, Kathryn Gorski, Pooja Chandra, Jyothi Manohar, Daniela Guevara, John Otilano, Jenna Moyer, Marvel Tranquille, Sarah Ackermann, Jared Capuano, Cynthia Cheung, Thomas A. Caiazza, Phoebe L. Reuben, Anastasia Murray Tsomides, Adriana Irizarry, Michael Sigouros, David Wilkes, Abigail King, Troy Kane, Majd Al Assaad, Wael Al Zoughbi, Kentaro Ohara, Joonghoon Auh, Peter Waltman, Florencia P. Madorsky Rowdo, Enrique Podaza, Valerie Gallegos, John Nguyen, Raehash Shah, Manish Shah, Allyson Ocean, Douglas Scherr, Nasser Altorki, Melissa Frey, Ana M. Molina, Lisa Newman, Vivan Bea, Eloise Chapman-Davis, Marcus D. Goncalves, Ashish Saxena, Parul J. Shukla, Kevin Holcomb, Rachel Simmons, Scott Tagawa, Jonathan H. Zippin, Evelyn Cantillo, Rohit Chandwani, Melissa Davis, Kelly Garrett, Pashtoon M. Kasi, Jennifer Marti, David Nanus, Jones T. Nauseef, Elizabeth Popa, Momin T. Siddiqui, Alicia Alonso, Cora N. Sternberg, Bishoy M. Faltas, Olivier Elemento, Juan Miguel Mosquera, Andrea Sboner, M. Laura Martin
Other articles featuring Olivier Elemento on OncoDaily.