Robert Orlowski, Deputy Chair of Lymphoma/Myeloma, Vice Chair of MM Research, and Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared a post on X:
“Myeloma Paper of the Day:
Mezigdomide reverses T-cell exhaustion through degradation of IKZF1/IKZF3 and reinvigoration of cytokine production pathways, and enhanced target cell killing with alnuctamab, a B-cell maturation antigen targeting TCE.”
Title: Mezigdomide reverses T-cell exhaustion through degradation of IKZF1/IKZF3 and reinvigoration of cytokine production pathways
Authors: Hsiling Chiu, Junfei Zhao, Tara Basavanhally, Chih-Chao Hsu, Michael D. Amatangelo, Gaurav Jain, Chad C. Bjorklund, Ting-Hsiang Huang, Lucia Y. Chen, Thomas A. Milne, Sarah Gooding, Samir Parekh, Anita Krithivas Gandhi, Maria Ortiz Estevez, Patrick Ryan Hagner
You can read the Full Article in Blood.

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