Morgan Fox, Graduate Student in Cancer Biology PhD Program at University of Colorado Anschutz Medical Campus, shared a post on X:
“I’m excited to share our article in press in Nature Communications!
This project encompasses the bulk of my dissertation research, investigating the role of FGFR1 in ER+ breast cancer brain metastasis.
For this project, we utilized models of ER+ brain metastases in both young and aged mice, and demonstrated that ligand-dependent FGFR1 activation from the brain microenvironment drives the initial outgrowth of brain metastases.
While the source of FGFR1 activation changes with age and estrogen depletion, brain metastatic outgrowth could be prevented with FGFR kinase inhibitors in both young and old animals.
This work wouldn’t have been possible without the amazing work from everyone who helped with the project, the input from patient advocates including Lianne Kraemer, and the guidance and mentorship of Diana Cittelly.
This work has also been featured as an Editors’ Highlight”
Title: Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of estrogen receptor-positive breast cancer brain metastases
Authors: Morgan S. Fox, Jenny A. Jaramillo-Gómez, R. Alejandro Marquez-Ortiz, Karen L. F. Alvarez-Eraso, Maria J. Contreras-Zárate, Trinh C. Pham, Elaina N. Barela, Stella N. Koliavas, Peter Kabos, Natalie J. Serkova, Carol A. Sartorius, Elizabeth A. Wellberg, Diana M. Cittelly
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