Mazyar Shadman: Zanubrutinib Plus Sonrotoclax vs Acalabrutinib Plus Venetoclax in Treatment-Naïve CLL
Mazyar Shadman/fredhutch.org

Mazyar Shadman: Zanubrutinib Plus Sonrotoclax vs Acalabrutinib Plus Venetoclax in Treatment-Naïve CLL

Mazyar Shadman, Deputy Chief Medical officer at Fred Hutch, Professor of Department of Medicine, Hematology and Medical Oncology Division at University of Washington, shared a post on LinkedIn:

“Excited to share that global phase-3 randomized CELESTIAL-TNCLL-2 is now being officially introduced, and I’ll be presenting the Trial-in-Progress (TIP) abstract at ASCO26.

This study compares:

Zanubrutinib plus Sonrotoclax (SZ) vs. Acalabrutinib plus Venetoclax (AV) in patients with treatment-naïve CLL.

As we continue to move toward time-limited, all-oral regimens, an important question remains:

What is the optimal fixed-duration combination for CLL?

Looking forward to the discussion and insights from the community.”

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