Mashukur Rahman: Top 15 Clinical Trials to Watch at ASCO GU 2026
Mashukur Rahman/LinkedIn

Mashukur Rahman: Top 15 Clinical Trials to Watch at ASCO GU 2026

Mashukur Rahman, Resident Doctor at Bangladesh Medical University, Medical Officer at Directorate General of Health Services, shared a post on LinkedIn:

“Top 15 Clinical Trials to Watch

Prostate Cancer

Precision and Treatment Intensification

  1. CIPHER
    Platinum as a low-cost strategy in HRR-mutated mCRPC – expanding options beyond PARP inhibitors.
  2. PSMAaddition
    Lutetium-177 vipivotide tetraxetan moves earlier into mHSPC – radioligand therapy shifting to hormone-sensitive setting.
  3. PEACE-2
    Systemic intensification (abiraterone + ADT) combined with definitive prostate RT – optimizing local + systemic synergy.
  4. PEACE-3
    Radioligand + ARPI combination in mCRPC – targeting dual pathways in advanced disease.
  5. CAPItello-281
    AKT pathway inhibition in PTEN-deficient mHSPC – precision targeting of PI3K/AKT alterations.

Bladder and Urothelial Cancer

  1. ADC Revolution and Bladder Preservation
  2. KEYNOTE-B15 / EV-304
    Perioperative enfortumab vedotin + pembrolizumab – potential new backbone in MIBC.
  3. VOLGA
    Triplet ADC-based perioperative strategy in MIBC – pushing intensification forward.
  4. SunRISe-2
    Bladder-sparing TAR-200 + cetrelimab in BCG-unresponsive NMIBC – redefining organ preservation.

Precision oncology. Radioligand expansion. ADC dominance.

ASCO GU 2026 is shaping the next phase of GU cancer care.”

Mashukur Rahman

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