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Mario Balsa: Pan-Cancer Scale Reveals Distinct Clonality and Co Mutation Patterns
Mario Balsa/ LinkedIn

Mario Balsa: Pan-Cancer Scale Reveals Distinct Clonality and Co Mutation Patterns

Mario Balsa, Medical Oncology Resident at Catalan Institute of Oncology, shared a post on X:

“Pan-cancer at scale just got real…50,000+ tumors, 400+ subtypes!

  • One-third of drivers arise in non-canonical contexts.
  • Distinct clonality and co-mutation patterns reshape biology.
  • HLA genotype + LOH – not just biology, but TCR eligibility.

It’s not just what drives the tumor, it’s where the driver drives Are we underestimating immune escape at the genomic level when selecting patients for TCR-based therapies?”

Mario Balsa

Title: Cancer type-specific variation in patterns of driver alterations across 50,000 tumors

Authors: Chaitanya Bandlamudi, Daniel Muldoon, Ino de Bruijn, Mingxuan Zhang, Michael V. Gormally, Emily C. Harrold, Subhiksha Nandakumar, Shaleigh A. Smith, Mark Y. Jeng, Sydney Woods, Kanika Arora, Walid K. Chatila, Bastien Nguyen, Henry Walch, Jun Woo, Craig M. Bielski, Christopher Fong, Thinh N. Tran, Gaofei Zhao, Miika Mehine, Maria A. Perry, Sam E. Tischfield, Allison L. Richards, Suraj Rajendran, Hongxin Zhang, Christoph K. Kreitzer, Ronak Shah, Risha Huq, Jesse Galle, Tina Alano, Ramyasree Madupuri, Ritika Kundra, Justin Jee, Karl Pichotta, Michele Waters, Richard A. Hickman, Josephine K. Dermawan, Jie-Fu Chen, Anton Safonov, Konrad H. Stopsack, Ritesh R. Kotecha, Hira A. Rizvi, Claire F. Friedman, Pedram Razavi, Ezra Rosen,

Yonina R. Murciano-Goroff, Luc G.T. Morris, James A. Fagin, Ingo K. Mellinghoff, Ping Chi, Neerav N. Shukla, Adam J. Schoenfeld, Gregory J. Riely, Charles M. Rudin, Alexander Drilon, Jake June-Koo Lee, Hikmat A. Al-Ahmadie, Gopa Iyer, Anna M. Varghese, Eileen M. O’Reilly, Zsofia K. Stadler, Mark E. Robson, Ed Reznik, JianJiong Gao, Diana Mandelker, Irina Ostrovnaya, Satshil Rana, Gowtham Jayakumaran, Anita Bowman, Abhinita Mohanty, Anoop Rema Balakrishnan, Aijazuddin Syed, Ryan N. Ptashkin, Jacklyn Casanova-Murphy, Debyani Chakravarty, Ryma Benayed, Maria E. Arcila, Sarat Chandarlapaty, Helena A. Yu, Neal Rosen, Mark T.A. Donoghue, Christopher A. Klebanoff, Rona Yaeger, A. Rose Brannon, Ahmet Zehir, Marc Ladanyi, Nikolaus Schultz, David B. Solit, Michael F. Berger

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Mario Balsa

Other articles featuring Mario Balsa on OncoDaily.

A. Rose Brannon Abhinita Mohanty Adam J. Schoenfeld Ahmet Zehir Aijazuddin Syed Alexander Drilon Allison L. Richards Anita Bowman Anna M. Varghese Anoop Rema Balakrishnan Anton Safonov Bastien Nguyen cancer Chaitanya Bandlamudi Charles M. Rudin Christoph K. Kreitzer Christopher A. Klebanoff Christopher Fong Claire F. Friedman Craig M. Bielski Daniel Muldoon David B. Solit Debyani Chakravarty Diana Mandelker Ed Reznik Eileen M. O'Reilly Emily C. Harrold Ezra Rosen Gaofei Zhao Gopa Iyer Gowtham Jayakumaran Gregory J. Riely Helena A. Yu Henry Walch Hikmat A. Al-Ahmadie Hira A. Rizvi Hongxin Zhang Ingo K. Mellinghoff Ino de Bruijn Irina Ostrovnaya Jacklyn Casanova-Murphy Jake June-Koo Lee James A. Fagin Jesse Galle Jianjiong Gao Jie-Fu Chen Josephine K. Dermawan Jun Woo Justin Jee Kanika Arora Karl Pichotta Konrad H. Stopsack Luc G.T. Morris Marc Ladanyi Maria A Perry Maria E. Arcila Mario Balsa Mark E. Robson Mark T.A. Donoghue Mark Y. Jeng Michael F. Berger Michael V Gormally Michele Waters Miika Mehine Mingxuan Zhang Neal Rosen Neerav N. Shukla Nikolaus Schultz OncoDaily Oncology Pedram Razavi Ping Chi Ramyasree Madupuri Richard A. Hickman Risha Huq Ritesh R. Kotecha Ritika Kundra Rona Yaeger Ronak Shah Ryan N. Ptashkin Ryma Benayed Sam E. Tischfield Sarat Chandarlapaty Satshil Rana Shaleigh A. Smith Subhiksha Nandakumar Suraj Rajendran Sydney Woods Thinh N. Tran Tina Alano Walid K. Chatila Yonina R. Murciano-Goroff Zsofia K. Stadler