Isaias Hernandez, Postdoctoral Researcher at Centre de Recherche des Cordeliers, shared on LinkedIn:
“Excited and honored to be part of this incredible collaborative work, led by Raphaël Mattiuz Miriam Merad, and published in Science!
‘Dendritic cells control tertiary lymphoid structure development and maintenance in cancer.’
Tertiary lymphoid structures (TLSs) have emerged as one of the strongest predictors of response to cancer immunotherapy, yet the mechanisms governing their formation and maintenance have remained elusive.
In this study, we demonstrate that type 1 conventional dendritic cells (cDC1s) are the key orchestrators of functional TLSs throughout tumor development.
Our main findings include:
- cDC1s initiate TLS formation by priming T cells in tumor-draining lymph nodes.
- Once TLSs are established, their persistence relies on the local accumulation of cDC1s and sustained antigen presentation to both CD4⁺ and CD8⁺ T cells.
- These interactions preserve germinal center formation, T follicular helper cells, progenitor exhausted T cells, and antitumor IgG responses.
- Therapeutic expansion or activation of dendritic cells enhances TLS development, opening exciting new avenues to improve cancer immunotherapy.
This work highlights cDC1s as central regulators of TLS biology and provides a strong rationale for developing dendritic cell – targeted strategies to enhance antitumor immunity.
It was a privilege to contribute to such an outstanding international collaboration. Congratulations to all the authors on this exciting achievement! Read the publication here.”
Title: Dendritic cells control tertiary lymphoid structure development and maintenance in cancer
Authors: Raphaël Mattiuz, Jesse Boumelha, Emmanouil Aerakis, Jessica Le Berichel, Pauline Hamon, Laszlo Halasz, Abishek Vaidya, Brian Y. Soong, Emir Radkevich, Hye Mi Kim, Matthew D. Park, Romain Donne, Leanna Troncoso, Rachel A. Kaplan, Clotilde Hennequin, Isaias Hernández-Verdin, Lucía López, Frederika Rentzeperis, Darwin D’Souza, Medard Ernest Kaiza, Ian P. MacFawn, Meriem Belabed, Guillaume Mestrallet, Etienne Humblin, Raphaël Merand, Samarth Hegde, Jean-Christophe Lone, Giorgio Ioannou, Sinem Ozbey, Igor Figueiredo, Alexander Tepper, Hajer Merard, Nadine Serhan, Maximilian M. Schaefer, Jinping An, Ray A. Ohara, Erika Nemeth, Simon Goldstein, Amanda M. Reid, Moataz Noureddine, Alexandra Tabachnikova, Giulia Maria Piperno, Maria Tsoumakidou, Jalal Ahmed, Alexandros D. Polydorides, Nina Bhardwaj, Amaia Lujambio, Zhihong Chen, Edgar Gonzalez Kozlova, Seunghee Kim-Schulze, Joshua D. Brody, Michael Schotsaert, Christine Moussion, Sacha Gnjatic, Vladimir Roudko, Florent Ginhoux, Kenneth M. Murphy, Catherine Sautès-Fridman, Wolf Herman Fridman, Brian D. Brown, Thomas U. Marron, Federica Benvenuti, Jason G. Cyster, Hélène Salmon, Tullia C. Bruno, Nikhil S. Joshi, Alice O. Kamphorst, Miriam Merad
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