E. Shyam P. Reddy: How Cancer Cells Hide from the Immune System
E. Shyam P. Reddy, Professor and Director of the Cancer Biology Program, Department of Obstetrics and Gynecology at Morehouse School of Medicine, shared a post on LinkedIn about a recent article by Surajit Sinha et al, published in Cancer Discovery:
“When cancer metastasizes, or spreads in the body, it becomes much more deadly for patients with solid tumors. Researchers have long sought to understand how cancer cells adapt to changing environments and avoid the immune system when they spread.
Hernandez and his team identified a protein called GCN1 that can trigger a stress response inside cancer cells and help them hide from certain immune cells. They also discovered another protein called IMPACT that can block GCN1. IMPACT not only interferes with the stress response but also activates the immune system to target and fight the cancer cells. Even though cancer cells stop making IMPACT due to changes in their DNA, the team found that making cancer cells produce IMPACT again helped another treatment called immune checkpoint inhibitor (ICI) therapy, kill pancreatic cancer cells in mice.
This study shows that IMPACT could be used as a therapy to make cancer cells more visible to the immune system, making it easier for the body to fight them. The team says their therapy may work for many types of aggressive solid tumors and help prevent the cancer from coming back.”
Title: Expression of IMPACT curtails metabolic plasticity and augments NK cell killing to abrogate metastatic growth
Journal: Cancer Discovery
Authors: Surajit Sinha, Abir Kumar Panda, Rodrigo Xavier das Neves, Zeribe C. Nwosu, Ke Xu, Elke van Beek, Priyanka P. Desai, Sivasish Sindiri, Sruthi Chempati, Kirsten Remmert, Billel Gasmi, Linda Bojmar, Constantinos Zambirinis, Alexander J. Rossi, Reed I. Ayabe, Michael M. Wach, James D. McDonald, Samantha M. Ruff, Emily A. Verbus, Areeba Saif, Alyssa V. Eade, Carolina M. Larrain, Lindsay R. Friedman, Shreya Gupta, Alok Ranjan, Martha E. Teke, Tahsin M. Khan, Tracey Pu, Amber Leila Sarvestani, Carrie E. Ryan, Jacob T. Lambdin, Kenneth Luberice, Stephanie N. Gregory, Stephanie C. Lux, Hanna Hong, Allen J. Luna, Imani A. Alexander, Sarfraz R. Akmal, Shahyan U. Rehman, Ashley Rainey, Todd D. Prickett, Vishal N. Koparde, Samantha Sevilla, Skyler A. Kuhn, King Chan, Zhonghe Sun, Nina Bubunenko, Eileen Li, Cathleen Hannah, Geneti Gaga, Thorkell Andresson, Margaret C. Cam, Xiaolin Wu, Lisa M. Jenkins, Andrew M. Blakely, Jeremy L. Davis, Giorgio Trinchieri, Pankaj K. Singh, James C. Yang, Marina Pasca di Magliano, Costas A. Lyssiotis, Michael B. Yaffe, Ethan M. Shevach, Jonathan M. Hernandez
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