EAU-YAU Renal Cancer Working Group shared a post on X:
“The most comprehensive evidence synthesis to date on IVC thrombectomy in RCC, now published in European Urology Oncology.
A global collaborative effort advancing surgical insight in one of the most complex challenges in uro-oncology.
PROSPERO-registered systematic review of PubMed, Embase, Scopus, and Web of Science identified 66 studies: 35 open (2434 pts), 12 laparoscopic (140 pts), 12 robotic (317 pts), and 7 comparative studies. Evidence was synthesized using meta-analysis & network meta-analysis
3241 patients (mean age 59.8 yr, tumor size 9.0 cm). Open surgery treated more advanced thrombi (Mayo III–IV: 37% vs 23% robotic, 4% laparoscopic). MIS reduced blood loss (254–918 vs 1488 ml), major complications (2.8–5.1% vs 12.9%), LOS, and overall complications (OR 0.24–0.37).
Over the study period, robotic approaches showed the fastest publication growth (+17%/yr).
MIS shows favorable perioperative outcomes in selected patients and experienced centers. However, substantial selection bias limits robust comparisons with open surgery, highlighting the need for high-quality prospective evidence.”
Title: Surgical Management of Nonmetastatic Renal Cell Carcinoma with Inferior Vena Cava Thrombus: A Systematic Review and Network Meta-analysis
Authors: Daniele Amparore, Savio Domenico Pandolfo, Riccardo Bertolo, Selcuk Erdem, Pietro Diana, Laura Marandino, Stijn Muselaers, Carlotta Palumbo, Nicola Pavan, Angela Pecoraro, Alberto Piana, Georges Mjaess, Eduard Roussel, Zhenjie Wu, Giovanni Cacciamani, Riccardo Campi, Michele Marchioni, European Association of Urology Young Academic Urologists Renal Cancer Working Group
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