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Daisuke Kotani
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Daisuke Kotani: The MEK-RAF Molecular Glue IK-595

Daisuke Kotani, GI Medical Oncologist, Chief Physician at the Department of Gastrointestinal Oncology at the National Cancer Center Hospital East, Japan, shared a post on X about a paper by Eric Haines et al. published in Nature Cancer:

“The MEK-RAF molecular glue IK-595 Nature Cancer.

  • Traps MEK-RAF complexes to prevent CRAF-mediated reactivation
  • Wider therapeutic window: efficacy with transient exposure and lower toxicities.
  • Potent in KRAS/BRAF-mutant CRC.”

Title: The MEK–RAF molecular glue IK-595 has potent antitumor activity across RAS/MAPK pathway-altered cancers

Authors: Eric Haines, Michael Burke, Rachel Catterall, Victor De Jesus, Daniel Hidalgo, Bin Li, Joseph D. Manna, Ao Yang, Jill Cavanaugh, Sarah R. Wessell, Marta Sanchez-Martin, Alexander Ivliev, Wilmin Bartolini, Sergio Santillana, Jeffrey Ecsedy, Michelle X. Zhang, Sabine K. Ruppel

You can read the Full Article in Nature Cancer.

Daisuke Kotani: The MEK-RAF Molecular Glue IK-595

More posts featuring Daisuke Kotani.

Alexander Ivliev Ao Yang Bin Li cancer Daisuke Kotani Daniel Hidalgo Eric Haines Jeffrey Ecsedy Jill Cavanaugh Joseph D. Manna Marta Sanchez-Martin Michael Burke Michelle X. Zhang OncoDaily Oncology Rachel Catterall Sabine K. Ruppel Sarah R. Wessell Sergio Santillana Victor De Jesus Wilmin Bartolini