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Constantinos Zambirinis: How CCL3-Producing Aged Neutrophils Promote Tumor Growth Across Cancers
Constantinos Zambirinis

Constantinos Zambirinis: How CCL3-Producing Aged Neutrophils Promote Tumor Growth Across Cancers

Constantinos Zambirinis, Surgical Oncologist and Docent at Linköpings universitet shared a post on X:

“New in Cancer Cell: Tumors leverage hypoxia to “lock” infiltrating Neutrophils into a terminally aged, CCL3-hi state. This triggers an autocrine CCL3-CCR1 survival loop that sustains TANs, and fuels tumor progression across multiple cancer types.”

Constantinos Zambirinis

Title: CCL3 is produced by aged neutrophils across cancers and promotes tumor growth

Authors: Evangelia Bolli, Pratyaksha Wirapati, Mehdi Hicham, Yuxuan Xie, Marie Siwicki, Florent Duval, Anne-Gaëlle Goubet, Máté Kiss, Béatrice Zitti, Thomas Zwahlen, Sheri Mcdowell, Ruben Bill, Simona Angerani, Camilla Engblom, Seth Anderson, Aiping Jiang, Oliver Hartley, David B. Sykes, Maja Jankovic, Nadine Fournier, Matthias Gunzer, David Tarussio, Stéphanie Tissot, Peter M. Sadow, William C. Faquin, Moshe Sade-Feldman, Ralph Weissleder, Sara Pai, François Mercier, Robert Manguso, Mikaël J. Pittet

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Constantinos Zambirinis

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Aiping Jiang Anne-Gaëlle Goubet Béatrice Zitti Camilla Engblom cancer CCL3-CCR1 Constantinos Zambirinis David B. Sykes David Tarussio Evangelia Bolli Florent Duval François Mercier Maja Jankovic Marie Siwicki Máté Kiss Matthias Gunzer Mehdi Hicham Mikaël J. Pittet Moshe Sade-Feldman Nadine Fournier Oliver Hartley OncoDaily Oncology Peter M. Sadow Pratyaksha Wirapati Ralph Weissleder Robert Manguso Ruben Bill Sara Pai Seth Anderson Sheri Mcdowell Simona Angerani Stéphanie Tissot Thomas Zwahlen William C. Faquin Yuxuan Xie