Bishal Gyawali, Medical Oncologist, Professor at Queen’s University, shared a post by Piet Ost, Radiation Oncologist at Iridium Network Antwerp, on X, adding:
”Deescalation trials do not need to be non inferiority.
A superiority design trial gets rid of all issues with NI –
- huge sample size
- arbitrary definition of what constitutes NI and
- inconclusive results despite 1000s of patients enrolled.”
Quoting Piet Ost‘s post:
”There should be a way to get around the huge numbers required to de-escalate a treatment…”
Title: De-escalation trials do not always need to be noninferiority: a case for superiority design de-escalation trials in oncology
Author: Bishal Gyawali
Other articles featuring Bishal Gyawali and Piet Ost on OncoDaily.