Angela Mastronuzzi, Head of Neuro-Oncology Unit at Bambino Gesù Children’s Hospital and President of AIEOP, shared a post on LinkedIn about a paper she co-authored with colleagues published in Journal of Neuro-Oncology by Springer Nature:
“Diagnostic and predictive molecular biomarkers in brain tumors across the lifespan: an age-stratified consensus statement- just published with the Journal of Neuro-Oncology by Springer Nature.
Molecular profiling has significantly advanced neuro-oncology, enabling the integration of biomarkers into the diagnosis and management of brain tumors. Precision medicine is emerging as a promising strategy; however, the marked heterogeneity of central nervous system tumors results in a low prevalence of actionable targets, limiting clinical applicability.
A multidisciplinary expert panel conducted a systematic review of the literature and developed a consensus statement addressing key predictive biomarkers across pediatric, adolescent and young adult (AYA), adult, and elderly populations. Evidence was evaluated for diagnostic, prognostic, and therapeutic relevance.
Based on current evidence and expert opinion, there is a need for age-adapted testing strategies, multidisciplinary molecular tumor boards, and increased clinical trial availability for patients with rare or emerging biomarkers. These recommendations aim to support the implementation of precision medicine and improve outcomes across all age groups.
We would like to thank Associazione IRENE Odv for their valuable support. This work is conducted on behalf of the Virtual Institute of Neuro-Oncology.”
Title: Diagnostic and predictive molecular biomarkers in brain tumors across the lifespan: an age-stratified consensus statement
Authors: Angela Mastronuzzi, Enrico Franceschi, Federica D’Antonio, Elisa Bennicelli, Giulia Berzero, Eugenia Cella, Massimo Filippi, Gaetano Lanzetta, Enrico Marchioni, Claudia Milanaccio, Matteo Simonelli, Paola Bini, Antonio Silvani, Andrea Pace
You can read the full article in Journal of Neuro-Oncology.
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