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Adam B. Weiner: Same Cancer Control, Better Side Effect Profile
Adam Weiner/X

Adam B. Weiner: Same Cancer Control, Better Side Effect Profile

Adam B. Weiner, Urologist at Cedars Sinai Medical Center, shared a post on X:

“Tansdermal Estradiol (tE2) vs ADT for locally advanced prostate cancer.

NEJM – New phase 3 RCT (PATCH/STAMPEDE-1)

tE2 patches are noninferior to LHRH agonists for metastasis-free survival (n=1,360)

  • 87.1% vs 85.9% 3-yr MFS
  • Way fewer hot flashes (44% vs 89%)
  • Lower fracture rates
  • More gynecomastia

Same cancer control. Better side effect profile. Patient-applied. Cheaper.

Time to rethink ADT?

Title: Transdermal Estradiol Patches in Locally Advanced Prostate Cancer

Authores: Ruth E. Langley, Duncan C. Gilbert, Stephen Mangar, Stuart Rosen, Ellie Bourmaki, Hannah L. Rush, Subramaniam Kananga Sundaram, Abdulla Alhasso, Roger Kockelbergh, Hoda Abdel-Aty, Claire L. Amos, Louise Brown, Simon Brown, Charlene Carvalho, Kitty Chan, Gerald Collins, William Cross, John Deighan, Sanjay Dixit, Trinh Duong, James Dyer, Joanna Gale, Silke Gillessen, Anna Griffiths, Marc Laniado, Anna Lydon, Neil McPhail, Archie MacNair, Sanjeev Madaan, John Marshall, David Matheson, Robin Millman, Wael Mohamed, Laura Murphy, Krishna Narahari, Christopher Parker, Miguel Panades, Alvan Pope, Arpita Raval, Angus Robinson, Martin Russell, Christopher Scrase, Matthew Sydes, Rafal Turo, Ram Venkitaraman, Simona Wade, Howard Kynaston, Gerhardt Attard, Nicholas D. James, Noel Clarke, Mahesh K. Parmar, D.Phil., and Matthew Nankivell.

Read the full article here.”

Adam B. Weiner

Other articles featuring Adam B. Weiner on OncoDaily.

Abdulla Alhasso Adam B. Weiner ADT Alvan Pope Angus Robinson Anna Griffiths Anna Lydon Archie MacNair Arpita Raval cancer Charlene Carvalho Christopher Parker Christopher Scrase Claire L. Amos David Matheson Duncan C Gilbert Ellie Bourmaki Gerald Collins Gerhardt Attard Hannah L. Rush Hoda Abdel-Aty Howard Kynaston James Dyer Joanna Gale John Deighan John Marshall Kitty Chan Krishna Narahari Laura Murphy LHRH Louise Brown Mahesh K. Parmar Marc Laniado Martin Russell Matthew Nankivell Matthew Sydes Miguel Panades Neil McPhail NEJM Nicholas D. James Noel Clarke OncoDaily Oncology prostate cancer Rafal Turo Ram Venkitaraman Robin Millman Roger Kockelbergh Ruth E. Langley Sanjay Dixit Sanjeev Madaan Silke Gillessen Simon Brown Simona Wade Stephen Mangar Stuart Rosen Subramaniam Kananga Sundaram Tansdermal Estradiol (tE2) Trinh Duong Wael Mohamed William Cross