Gustavo Viani, Professor at Faculty of Medicine of Botucatu, São Paulo State University (UNESP), shared on LinkedIn:
“After Prostatectomy: Does Adding Hormone Therapy to PORT Really Save Lives? (IPD Meta-analysis)
Aim:
Test whether adding hormone therapy (short- or long-term) to post-op RT (PORT) and outcomes after radical prostatectomy
Methods
-IPD meta-analysis of 6 RCTs
-n=6,057; median FU 9y
– Arms: PORT+HT vs PORT alone
Results
-OS: No meaningful benefit
(HR 0.87; p=0.06)
– MFS was increased (HR 0.79; p<0.001), mainly when pre-PORT PSA >0.5 ng/mL
Conclusion
-Long-term HT may increase OS only if PSA >1.6
– Need biomarkers to select who benefits”
Title: Hormone therapy use and duration with postoperative radiotherapy for recurrent prostate cancer: an individual patient data meta-analysis
Authors: Amar U Kishan, Yilun Sun, Christopher C Parker, Paul Sargos, Matthew R Sydes, Sylvie Chabaud, Meryem Brihoum, Tahmineh Romero Kalbasi, Michael L Steinberg, Luca F Valle, Kekoa Taparra, Jonathan E Shoag, Jorge A Garcia, Jason R Brown, Matthew B Rettig, Adam E Singer, Robert E Reiter, Scott Eggener, Wayne Brisbane, Soumyajit Roy, Nicholas G Zaorsky, Angela Y Jia, Ting Martin Ma, Nicholas G Nickols, Jason A Efstathiou, Osama Mohamad, James J Dignam, Wendy F Seiferheld, Alan Pollack, Howard M Sandler, Paul L Nguyen, Pascal Pommier, Daniel E Spratt
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