Yan Leyfman, Medical Oncologist, Co-Founder and Executive Director of MedNews Week, shared a post on LinkedIn:
“Pioneering work led by Dr. Zihai Li, MD, PhD and the team at The Ohio State University College of Medicine uncovers a new hallmark of T cell exhaustion – the proteotoxic stress response (Tex-PSR).
- Tex-PSR is marked by increased protein translation, protein aggregation, and stress responses that drive T cell dysfunction in chronic infections and cancer.
- Targeting these proteostasis pathways improved cancer immunotherapy responses in preclinical models.
- High Tex-PSR levels in patient T cells were linked to poor clinical outcomes.
This discovery opens the door to new strategies for overcoming T cell exhaustion and boosting the effectiveness of immunotherapies.”
More posts featuring Yan Leyfman.