Liang Cheng, Professor and Vice Chair at The Warren Alpert Medical School of Brown University, shared on X:
“The morphologic spectrum of intraductal and intra-acinar neoplasms of the prostate includes high-grade prostatic intraepithelial neoplasia (HGPIN), atypical intraductal proliferation (AIP), and intraductal carcinoma of the prostate (IDC-P). AIP is defined as an intraglandular proliferation with greater architectural complexity and/or cytologic atypia than HGPIN but insufficient for a diagnosis of IDC-P. IDC-P, traditionally regarded as retrograde intraductal spread of prostatic adenocarcinoma (PAC), is associated with adverse clinicopathologic features, as is AIP, and both demonstrate overlapping molecular profiles.
Rare cases of IDC-P not associated with invasive PAC are thought to represent a true precursor lesion. What’s new on the horizon? Take a look at this salient letter by Prof. Rodolfo Montironi Alessia Cimadamore just published today in European Urology.”
Title: Re: Lucia L. Rijstenberg, Hridya Harikumara, Esther I. Verhoef, et al. Identification of Intraductal-to-Invasive Spatial Transitions in Prostate Cancer: Proposal for a New Unifying Model on Intraductal Carcinogenesis. Histopathology 2025;86:1091–100
Authors: Rodolfo Montironi, Alessia Cimadamore, Antonio Lopez-Beltran, Liang Cheng
Read the full article on European Urology.
More posts from L. Cheng.