Swathi Arur: Asking The Right Question Changes The Cancer Care
Swathi Arur, Blanche Bender Professor of Cancer Research, and Deputy Chair, Department of Genetics at MD Anderson Cancer Center, shared a post on LinkedIn:
“This is a delayed post, but one I am proud to share!
The US Patent US-12173084-B2 has been granted to my lab for the use of phosphorylated DICER1 as a diagnostic marker for early-stage metastatic cancers. This journey began with C. elegans, where curiosity-driven experiments uncovered a fundamental regulatory mechanism for phosphorylated Dicer in governing the oocyte to embryo reprogramming event; published in Dev Cell, 2014.
It continued in mouse tumor models (Cancer Res, 2019; PNAS, 2019) with awesome collaborators, Neeraj Aryal and Lozano Guillermina, where we saw the biology unfold in real time and with my awesome student Raisa Reyes (Science Advances, 2023), we identified phosphorylated Dicer as a driver of tumor metastasis, which ultimately led to assaying human cancer patients with collaborator Don Gibbons, where the translational potential started to become clear (Science Advances, 2023).
To me, this is a vivid reminder that the path from science to medicine remains our most powerful tool as scientists seeking clinical impact, and that groundbreaking clinical advances often start with a question no one knew to ask in the lab.”
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