Medigene AG Expands its End-to-End Platform by Submitting Three Patents to the European Patent Office

Medigene AG an immuno-oncology platform company focusing on the discovery and development of T cell immunotherapies for solid tumors, today announced the submission of three patents to the European Patent Office. This underscores Medigene’s commitment to advancing T cell-based immunotherapies for the treatment of solid tumors.

Interferon-Gamma (IFNγ) Biosensor

The first patent submission covers the Company’s innovative Interferon-gamma (IFNγ) Biosensor, a technology that enables real-time monitoring and quantification of IFNγ release from cytokine-secreting cells. The proprietary technology allows to better understand immune response dynamics by utilizing a simplified and efficient cytometry detection method.

The IFNγ Biosensor technology overcomes the limitations of currently available commercial tools, which are often costly, time-consuming, and prone to errors due to complex procedures that diminish reproducibility. Additionally, conventional methods typically only allow for endpoint measurements and do not support real-time monitoring of IFNγ over extended periods which is made possible through use of this IFNγ Biosensor.

High Precision TCR Tracking (UniTope and TraCR)

Additionally, Medigene has filed two patents for its novel T cell receptor (TCR)-specific Antigen-Antibody combination technology, UniTope and TraCR. This technology incorporates a pair of tools designed to uniquely tag the TCR and exactly track its location.

This in turn allows precise evaluation of proliferation, persistence, and localization of a TCR-guided cell therapy, whether studied in vitro or in vivo, thereby offering critical insights into cell therapy efficacy, and mechanisms.

“The patent applications submitted to the European Patent Office further illustrate our unique scientific and technical approach as we further enhance our End-to-End (E2E) Platform by incorporating new proprietary technologies.

These innovative tools enable Medigene to increase the overall efficiency for the development of potential best-in-class TCRs and TCR-based therapies. They increase reproducibility in measuring parameters of safety and efficacy from early in the development process onwards, significantly reducing time and cost,” – stated Selwyn Ho, CEO at Medigene.

Medigene continually extends and strengthens its patent portfolio with new technologies and expands existing patents into additional jurisdictions. The Company maintains over 20 different patent families worldwide covering applications protecting Medigene’s 3S (sensitive, specific and safe) TCRs as well as its exclusive E2E Platform technologies.

About Medigene AG

Medigene AG is an immuno-oncology platform company dedicated to developing differentiated T cell therapies to effectively eliminate cancer. Its End-to-End Platform consists of multiple proprietary and exclusive technologies that generate optimal T cell receptors, armor and enhance these T cells to overcome the immunosuppressive tumor microenvironment (TME), and ensure the T cells drug product composition maximizes safety, efficacy and durability of response.

This creates potential best-in-class, T cell receptor engineered T cell (TCR-T) therapies to treat multiple solid tumor indications for both its in-house product pipeline and partnering. Medigene’s lead TCR-T program MDG1015 is on track for IND filing in 3Q 2024 and CTA filing in 4Q 2024. For more information, please visit medigene.com.

About Medigene’s End-to-End Platform

Medigene’s immunotherapies help activate the patient’s own defense mechanisms by harnessing T cells in the battle against cancer. Medigene’s End-to-End Platform combines multiple exclusive and proprietary technologies to create best-in-class, differentiated TCR-T therapies.

The platform includes multiple TCR generation and optimization technologies (e.g., Allogeneic-HLA (Allo-HLA) TCR Priming), as well as product enhancement technologies (e.g., PD1-41BB and CD40L-CD28 Costimulatory Switch Proteins, iM-TCR) to address challenges in developing effective, durable and safe TCR-T therapies. Partnerships with multiple companies including BioNTech and Regeneron, continue to validate the platform’s assets and technologies.

Other posts featuring Medigene AG on OncoDaily.