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Ryan Denu: MD Anderson Cancer Center experience with ‘triple-negative’ GIST lacking some alterations

Photo from Ryan Denu/X

May 3, 2024, 16:12

Ryan Denu: MD Anderson Cancer Center experience with ‘triple-negative’ GIST lacking some alterations

Ryan Denu, Oncology Fellow at MD Anderson Cancer Center, shared on X/Twitter:

“Hot off the press, our MD Anderson Cancer Center experience with ‘triple-negative’ gist that lack KIT/PDGFRA/SDH alterations. Thanks to Neeta Somaiah, Alexander Lazar, Anthony P Conley, Ravin Ratan, Dejka Araujo, Vinod Ravi, Elise Nassif Haddad, Michael Nakazawa.

Heterogeneous group though generally poor response to imatinib, more indolent biology, and favorable outcomes. Driver mutations in RAS/RAF/MAPK, DNA damage response, and FGFR pathways.

Summary of gist drivers.”

Ryan Denu: MD Anderson Cancer Center experience with 'triple-negative' GIST lacking some alterations

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Source: Ryan Denu/X

Alexander Lazar Anthony P Conley cancer Dejka Araujo DNA damage Driver mutations Elise Nassif Haddad FGFR pathways gist drivers imatinib KIT/PDGFRA/SDH MD Anderson Cancer Center Michael Nakazawa Neeta Somaiah OncoDaily Oncology RAS/RAF/MAPK Ravin Ratan Ryan Denu sarcoma Vinod Ravi

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