Helena Linardou: PAVE Trial in ES-SCLC Reveals Biomarker Insights and Future Precision IO Potential
Helena Linardou, Director, 4th Oncology Dept & Clinical Trials Center at Metropolitan Hospital, shared Giuseppe Banna’s post on X:
“Excited and proud to see our PAVE trial in ES-SCLC published in EJC!
Grateful to all the amazing investigators of HeCOG, and especially to my dear friend and ‘co-pilot’ Giannis Mountzios for the stellar collaboration throughout and beyond…
The PAVE trial tested intercalated avelumab + platinum–etoposide in extensive-stage SCLC.
Although 1-yr PFS not met
Key biomarker insights: TP53/RB1 co-mutations linked to prognosis, PCI benefit, QoL gains
Outcomes ~ historical chemo-IO
Smarter precision IO ahead.”
Title: Intercalated Avelumab plus platinum-based chemotherapy in patients with Extensive-Stage Small-Cell Lung cancer (PAVE): Final Outcome, Immunophenotypic and biomarker analysis of a multi-center phase II Hellenic Cooperative Oncology Group study.
Authors: Helena Linardou, Kyriaki Papadopoulou, Nikolaos Korfiatis, Anna Goussia, Epaminondas Samantas, Gerasimos Aravantinos, Athina Christopoulou, Nikolaos Spathas, Elena Fountzilas, Amanda Psyrri, Georgia-Angeliki Koliou, Soultana Meditskou, Epaminondas Kosmas, Mattheos Bobos, Antonia V. Charchanti, Ioannis Vamvakaris, Anna Koumarianou, Dimitrios Bafaloukos, Paris Kosmidis, George Fountzilas, Giannis Mountzios
Quoting Giuseppe Banna’s, Head of Translational Research and Clinical Trials Unit, Thoracic Tumours at Candiolo Cancer Institute IRCCS, post:
“Kudos to Helena Linardou, Giannis Mountzios and the Greek group for their relentless efforts in advancing SCLC care!
While the PAVE trial didn’t meet its primary endpoint, it delivered key insights on biomarkers (TP53/RB1 co-mutations) & PCI benefit paving the way for smarter IO use!”
More posts featuring Helena Linardou and Giuseppe Banna.
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