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Nicholas Hornstein: Guardant360 ctDNA Assays In Advanced Colorectal Cancer
Nicholas Hornstein/X
Jul 26, 2025, 03:45

Nicholas Hornstein: Guardant360 ctDNA Assays In Advanced Colorectal Cancer

Nicholas Hornstein, Assistant Professor at Northwell Health, shared a post on X:

“New paper out!

We reanalyzed raw sequencing data from 18,558 standard-of-care Guardant360 ctDNA assays in advanced colorectal cancer using a partner-agnostic fusion caller.

  • Fusions in 1.3% of patients  
  • 93% were subclonal — enriched after EGFR therapy
  •  Clonal fusions linked to MSI-H tumors  
  • Subclonal fusions may signal impending acquired resistance to targeted therapies like EGFR inhibitors — offering a window for earlier intervention.

Thanks to Andrew Pellatt for being a great co-fellow and letting me participate in this work along some of the defining leaders in CRC like Van Morris, Scott Kopetz, Ryan Huey!”

Title: Detection of oncogenic fusions in colorectal cance using a partner-agnostic next-generation sequencing approach

Authors: Andrew J. Pellatt, Reagan M. Barnett, Sante Gnerre, Kristin Edwards, Jason A. Willis, Michael J. Overmann, Kanwal Raghav, Christine M. Parseghian, Arvind Dasari, M. Pia Morelli, Alisha Bent, Madhulika Eluri, Nicholas Hornstein, Leylah M. Drusbosky, Scott Kopetz, Van K. Morris

Read the full article here

Detection of oncogenic fusions in colorectal cancer

More posts featuring Nicholas Hornstein on OncoDaily.

Alisha Bent Andrew J. Pellatt Arvind Dasari cancer Christine M. Parseghian colorectal cancer EGFR inhibitors EGFR therapy Guardant360 Jason A. Willis Kanwal Raghav Kristin Edwards Leylah M. Drusbosky M. Pia Morelli Madhulika Eluri Michael J. Overmann MSI-H Tumors Nicholas Hornstein OncoDaily oncogenic fusions Oncology partner-agnostic next-generation sequencing approach Reagan M. Barnett Ryan Huey Sante Gnerre Scott Kopetz Van K. Morris
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