Myeloma Paper of the Day, May 21st, suggested by Robert Orlowski
Robert Orlowski, Deputy Chair of Lymphoma/Myeloma, Vice Chair of MM Research and Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared a post on X:
“Myeloma Paper of the Day: Anti-BCMA CAR T cells over-expressing granzyme B-NOXA fusion protein show improved killing of myeloma in both in vitro and in xenograft mouse models in vivo by localizing NOXA to cytotoxic granules and inhibition of MCL-1.”
Title: Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation
Authors: Thomas Kimman, Marta Cuenca, Ralph G. Tieland, Dedeke Rockx-Brouwer, Jasmijn Janssen, Benjamin Motais, Anne Slomp, Corine Pleijte, Sabine Heijhuurs, Angelo D. Meringa, Wendy Boschloo, Douwe MT Bosma, Sanne Kroos, Vania lo Presti, Joost P. G. Sluijter, Stefan Nierkens, Niels Bovenschen, Jürgen Kuball, Alain van Mil, Monique C. Minnema, Zsolt Sebestyén, Victor Peperzak.
You can read the Full Article in Nature Communications.
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