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Patrick Hwu: Can low-dose gut irradiation enhance the effectiveness of PD-L1 blockade in metastatic cancer?
Patrick Hwu/X
Apr 26, 2025, 15:08

Patrick Hwu: Can low-dose gut irradiation enhance the effectiveness of PD-L1 blockade in metastatic cancer?

Patrick Hwu, President and CEO at Moffitt Cancer Center, shared on X:

“Can low-dose gut irradiation enhance the effectiveness of PD-L1 blockade in metastatic cancer? PD-L1 blockade therapy works by lifting the ‘brakes’ on the immune system, helping T cells attack tumors more effectively, but not all patients respond.

In this study, Chen, Eric Deutsc, and other researchers Gustave Roussy tested intestinal low-dose radiotherapy (ILDR) in patients who had previously shown resistance to anti-PD-1 therapy. The results suggest ILDR, followed by restarting immunotherapy, may boost response rates.

This approach offers a potential new way to overcome resistance by modulating the gut environment.”

Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients

Authors: Jianzhou Chen et al.

Patrick Hwu

Ai-Ling Tian Aitziber Buqué Anne-Laure Mallard de La Varende Antonin Levy cancer Carolina Alves Costa Silva Cecilia Monge Céline Clémenson Charlotte Robert Chengbing Zeng Chiara Arilli Christophe Massard Chuangzhen Chen Clément Quevrin Conrad Rauber Daphne Morel Eloise Lopes Elson Santos Neto Eric Deutsch Eugénie Pizzato Gianmarco Piccinno Guido Kroemer Guoxin Cai Gustave Roussy Hannah Felchle ILDR Jennifer C. Jones Jianzhou Chen Julius Clemens Fischer Laurence Zitvogel Lisa Derosa Lisa Sitterle Liwei Zhao Lorenzo Belluomini Lorenzo Galluzzi Lydia Meziani Maike Trommer Marcos P. Camandaroba Marine Fidelle metastatic cancer Michele Mondini Misha Mao Monica Mangoni Nicola Segata OncoDaily Oncology Patrick Hwu Peng Liu Peter Holicek Pierre Blanchard Pierre Ly Pierre-Antoine Laurent Pierre-Edouard Fournier Qingxin Cai Rachel P. Riechelmann radiotherapy Roger Sun Sandra Demaria Sebastian Neppl Silvia Formenti Simon Thomas Simone Wegen Sylvère Durand Tim F. Greten Valeria Dionisi Valerio Iebba Vanessa Di Cataldo Xuehan Huang Yizhou Zhan
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